In the meantime, the "move of calcium ion" is also seen in other systems and organisms. For example, old person usually suffers from arteriosclerosis related to calcareous deposit while he or she may be in short of calcium in the body. When calcium is short in organism, a lot of patients with nephrolith may suffer osteoporosis and hyperosteogeny simultaneously. Therefore, the key question to solve "three highs and one low" phenomenon is to supply sufficient calcium.

In the past 12 years, the Medical School of Harvard University has conducted a survey among the patients with kidney calculus on the calcium supply and risks resulted from nephrolith. The survey discovered that "the women who don't eat much calcareous food are more likely to suffer nephrolith than those who do." The survey, which was focused on nearly 100,000 women, also discovered that the calcium taken by these women everyday is mainly from dairy products, and chances to suffer nephrolith for the women whose daily consumption of calcareous averaged 1,098 grams are 35% less than those who take only 488 grams of calcareous everyday. In addition, concentration of the calcium citrate existing in the patient's urine will be increased when calcium citrate is supplied. Since nephrolith is usually caused by low citrate urine, the increase of the calcium citrate existing in urine can decrease the crystal of nephrolith. As a result, the chances to suffer nephrolith will be effectively reduced.